Document Type

Article

Publication Date

5-2009

Abstract

Highlights the examples of Thiopurine S-methyltransferase (TPMT) and Warfarin as a means of describing some of the problems that are common to many pharmacogenetic cases. The pharmacogenetic literature contains many examples of confusing, or even contradictory, studies that arise due to unknown environmental factors that result in poor outcomes; drugs whose metabolism/transport are affected by multiple genes in multiple pathways; and clinically important genes that have many rare allelic variants with similar phenotypes variation in the frequencies of allelic variants among ethnic groups that mask the role of any one variant. These issues are common to most gene/drug dynamics and do not preclude the importance of pharmacogenetic studies. They do call for more realistic assessments of the role of genetic testing for the practicing clinician as this field develops.

Comments

Article published in 2009 in Lab Medicine:

Brazeau, D.A. and Brazeau, G. A. Role of the Genomics Revolution in Pharmaceutics. Lab Medicine. 2009; 40:261-266; doi:10.1309/U0WIGLRLLMUQYN

Files over 3MB may be slow to open. For best results, right-click and select "save as..."

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.