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ELCS In Ice: Cryo-electron Microscopy Of Nuclear Envelope Limited Chromatin Sheets
Mikhail Eltsov, Sergey Sosnovksi, Ada L. Olins, and Donald E. Olins
Nuclear Envelope-Limited Chromatin Sheets (ELCS) form during excessive interphase nuclear envelope growth in a variety of cells. ELCS appear as extended sheets within the cytoplasm connecting distant nuclear lobes. Cross-section stained images of ELCS, viewed by transmission electron microscopy, resemble a sandwich of apposed nuclear envelopes separated by ~30 nm, containing a layer of ordered chromatin fibers. EM Procedures: The ultrastructure of ELCS was compared by three different methods:... Read More
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Sex and Haplotype Associations with Adverse Effects of Calcineurin Inhibitors Post-Renal Transplant
Daniel A. Brazeau, Calvin Meaney, Shirley Chang, Rocco Venuto, Nick Leca, Aijaz Gundroo, Sarah Morse, Joseph Consiglio, Louise Cooper, and Kathleen Tornatore
BACKGROUND: P-glycoprotein (P-gp), an ABC transport protein contributes to the interpatient pharmacokinetic and pharmacodynamic variability of calcineurin inhibitors(CNI), tacrolimus(TAC) and cyclosporine (CYA). ABCB1 encodes P-gp and the single nucleotide polymorphisms (SNP) 1236C>T, 2677G>T/A, 3435C>T may alter protein expression or function. Our objective was to examine the association of ABCB1 haplotypes, sex and race with chronic CNI adverse effects (AE) in renal transplant recipients (RTR). METHODS: A meta-analysis of 3... Read More
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Racial Influence on ABCB1 Gene Expression in Peripheral Blood Mononuclear Cells in Stable Renal Transplant Recipients
Daniel A. Brazeau, Kathleen Tornatore, Aijaz Gundroo, and Rocco Venuto
Background: Immunosuppressive therapy (IT) such as tacrolimus are influenced by pglycoprotein (P-gp) which modulates cellular efflux of this drug. P-gp is present on peripheral mononuclear cells (PBMC) and is encoded by the ABCB1 gene. No data are available regarding the impact of race on ABCB1 gene expression in PBMCs post-transplant over IT dosing interval. Methods: An observational study was completed in 20 African American (AA) and 11 Caucasian (C)... Read More
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