Faculty Advisor(s)

Cheryl Nimmo

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© 2019 Vanessa Pasquariello


An amniotic fluid embolism (AFE) occurs when amniotic fluid enters maternal circulation, causing a physical obstruction or an anaphylactoid reaction, both of which are often detrimental to the parturient patient. This paper reviews a series of studies to examine the incidence, risk factors, presentation, and management of an AFE in the healthcare setting. Diagnosing an AFE remains difficult as a universal diagnostic criterion does not exist (aside from in reported research); thus, its identification is often made when another differential diagnosis fails to manifest. The presentation of the following biomarkers: squamous cell carcinoma antigen, CK13, and CK10/13 can aid in the investigation of an AFE event. Management of an AFE takes a comprehensive approach with considerations to cardiac resuscitation, post-cardiac arrest care, hemodynamic support, coagulopathy, and uterine atony. New and unconventional methods in the treatment of an AFE have been suggested in three case studies using C1INH, lipid emulsion therapy, and atropine/ondansetron/ketorolac.


Master's capstone



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