Faculty Advisor(s)

David Harris

Document Type


Publication Date

Summer 2020


© 2020 Marguerite Mullin


Retinoblastoma (RB) is a rare pediatric cancer commonly diagnosed in patients at a very young age. New therapies for this disease are emerging that involve some degree of sedation, requiring anesthesia providers to be involved in their care. Intraarterial chemotherapy (IAC) is one of these new exciting treatment options and requires general anesthesia. Multiple studies and case reports have reported a sudden decrease in pulmonary compliance during IAC for RB and attribute this response to the trigemino-cardiac reflex (TCR). Once this event occurs, patients experience associated hypoxemia, hypotension, bradycardia, and cardiovascular collapse. A systematic literature review was aimed at educating the anesthesia provider on the signs and symptoms, pathophysiology, diagnosis and treatment options for patients with RB as well as identifying possible risk factors for developing this phenomenon.


Master's capstone



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