Phosphatidylserine Colocalizes With Epichromatin In Interphase Nuclei And Mitotic Chromosomes

Authors

Igor Prudovsky
Calvin P.H. Vary
Yolanda Markaki
Ada L. Olins, University of New EnglandFollow
Donald E. Olins, University of New EnglandFollow

Document Type

Article

Publication Date

3-3-2012

Abstract

Cycling eukaryotic cells rapidly re-establish the nuclear envelope and internal architecture following mitosis. Studies with a specific anti-nucleosome antibody recently demonstrated that the surface (“epichromatin”) of interphase and mitotic chromatin possesses a unique and conserved conformation, suggesting a role in postmitotic nuclear reformation. Here we present evidence showing that the anionic glycerophospholipid phosphatidylserine is specifically located in epichromatin throughout the cell cycle and is associated with nucleosome core histones. This suggests that chromatin bound phosphatidylserine may function as a nucleation site for the binding of ER and re-establishment of the nuclear envelope.

Comments

Article originally published by Taylor & Francis Group in Nucleus on 01/03/12, available online: http://www.tandfonline.com/10.4161/nucl.19662

Copyright © 2012 Landes Bioscience.

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

Recommended Citation

Prudovsky, Igor; Vary, Calvin P.H.; Markaki, Yolanda; Olins, Ada L.; and Olins, Donald E., "Phosphatidylserine Colocalizes With Epichromatin In Interphase Nuclei And Mitotic Chromosomes" (2012). Pharmaceutical Sciences Faculty Publications. 18.
https://dune.une.edu/pharmsci_facpubs/18