Highlights the examples of Thiopurine S-methyltransferase (TPMT) and Warfarin as a means of describing some of the problems that are common to many pharmacogenetic cases. The pharmacogenetic literature contains many examples of confusing, or even contradictory, studies that arise due to unknown environmental factors that result in poor outcomes; drugs whose metabolism/transport are affected by multiple genes in multiple pathways; and clinically important genes that have many rare allelic variants with similar phenotypes variation in the frequencies of allelic variants among ethnic groups that mask the role of any one variant. These issues are common to most gene/drug dynamics and do not preclude the importance of pharmacogenetic studies. They do call for more realistic assessments of the role of genetic testing for the practicing clinician as this field develops.
Brazeau, Daniel A. and Brazeau, Gayle A., "Role of the Genomics Revolution in Pharmaceutics" (2009). Pharmaceutical Sciences Faculty Publications. 5.