Perspective Chapter: Multi-Omic Approaches To Vaccine Development Against Helminth Diseases

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Though the past three decades have led to a renaissance in vaccine design, the development of vaccines that protect against helminth diseases remains elusive. The need for protective vaccines for humans and livestock remains urgent because of the side-effect profiles of anti-helminthic drugs and the growing incidence of antimicrobial resistance and declining efficacy. The “-omics” era has led to renewed interest in vaccine development against helminth diseases, as candidate vaccines can now be designed, evaluated, and refined in a fraction of the time previously required. In this chapter, we describe and review genomic, transcriptomic, and proteomic approaches to the design of vaccines against helminth diseases.


Chapter from open access book Parasitic Helminths and Zoonoses - From Basic to Applied Research:

Daga, V., Green, E., Ravichandran, P., Short, M., & May, M. (2022). Perspective Chapter: Multi-Omic Approaches to Vaccine Development against Helminth Diseases. IntechOpen. doi: 10.5772/intechopen.102621

Authors Daga, Green, Ravichandran, and Short were University of New England College of Osteopathic Medicine students at time of publication; author May is a member of the University of New England faculty.