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Developing Burrowing As A Non-Evoked Readout Assessment For Novel Analgesic Drug Efficacy
Kayla Lindros, Denise Giuvelis, and Ed Bilsky
Traditional drug development efforts to diminish the problem of chronic pain rely heavily on pain-evoked assays that can yield false positives, leading to confounding assessments of novel drugs. To avoid this, we are looking at burrowing as a novel readout assessment of analgesic efficacy. Preliminary data shows that induction of post-surgical pain reduces this innate behavior by about 35%. In attempt to increase this number, we tested a variety... Read More