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Statins are one of the most heavily prescribed medications. The 2018 ACC/AHA guidelines support statin therapy for most older adults, but recommendations are less clear for those over 75. The literature was systematically reviewed for evidence of the efficacy of statin treatment in different patient populations. Significant evidence was found supporting a decreasing association between low-density lipoprotein cholesterol (LDL-C) and mortality as well as decreasing statin efficacy with increasing age. The consequences of unnecessary statin therapy can be severe for older adults. Improved methods for evaluating atherosclerotic cardiovascular disease (ASCVD) risk, such as using negative markers to help identify those who may not benefit from statin therapy, should be more widely employed.
Pharmacy and Pharmaceutical Sciences
© 2019 The Authors
White, Alyssa M. B.; Mishcon, Hillary R.; Redwanski, John; and Hills, Ronald D. Jr, "Efficacy Of Statin Therapy In The Elderly" (2019). Pharmacy Student Posters. 2.